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Session: Poster session I
Session starts: Thursday 24 January, 15:00

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Romana Perinajová (TU Delft)
Merel Toussaint (TU Delft)
Pim van Ooij (Amsterdam Medical Centre)
Saša Kenjereš (TU Delft)

Abstract:
Intracranial aneurysms cause almost 500,000 deaths in the world every year. Currently, the processes behind their genesis and rupture are not well known. New opportunities for both the treatment as well as the prevention may be found if we have better understanding these processes. Here we show how the combination of Magnetic Resonance Imaging (MRI) and Computational Fluid Dynamics (CFD) provides a non-invasive alternative for studying the intracranial aneurysm. The importance of boundary conditions in an aneurysm simulation was assessed by comparing the simulation results to 7T MRI velocity data, obtained from the Academic Medical Centre (AMC) in Amsterdam. Adequate similarities were found in velocity values, together with qualitative agreement in the wall shear stress. In previous studies, it was hard to find the precise location of rupture in an aneurysm. The aneurysm geometry of the CFD Rupture challenge from 2013 (J of Biomech. Eng. 2015) was simulated to predict the location of a known rupture site. This rupture location was predicted by combining few hemodynamic criteria. Namely, the time-averaged wall shear stress (WSSTA), oscillatory shear index (OSI) and vortex-saddle point structure during systole with accompanying local pressure minima. Thanks to a sensitivity study on these criteria a critical threshold for rupture risk was proposed and it was possible to predict the exact rupture site for the intracranial aneurysm from the CFD challenge. Therefore, the risk assessment of the rupture site in an aneurysm can be used as a more accurate tool to evaluate the need for a dangerous preventive surgery. By applying the same evaluation of the hemodynamical properties in the patient aneurysm, we were able to localize a possible rupture site in this case as well. These results are the first glance into the better understanding the origins of the aneurysm rupture.